Alicja Piotrowska

After obtaining M.Sc. in Biotechnology at Adam Mickiewicz University in Poznan, she started an interdisciplinary PhD program at Division of Molecular Biophysics, Poznan University. She contributes to an authentic research experiences in the laboratory of MNM Diagnostics to develop a cutting-edge approach to personalized genetics.

Personalized oncology is an approach to improve treatment of an individual patient by taking into account changes in an individual’s DNA. One aspect of this is an assessment of DNA repair mechanisms to tailor anti-cancer treatment based on patient genomic profiles. More specifically, the evaluation of DNA repair efficiency provides a unique opportunity to apply targeted cancer therapies. For example, the PARP inhibitors (PARPi) have recently entered the clinics for the treatment of Homologous Recombination (HR)-deficient cancers. We suggest that the comprehensive analysis of DNA repair pathway efficiencies, preferably achieved by cancer whole-genome sequencing provides a diagnostic tool for treatment selection and should be applied in day-to-day cancer diagnostics.


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